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KMID : 0604520090350020151
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 2 p.151 ~ p.158
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Hypopigmentary Effect of Milk Thistle Extract Silymarin
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Choo Soo-Jin
Ryoo In-Ja
Kim Young-Hee
Xu Guang-Hua
Kim Ki-Ho
Han Chang-Sung
Kim Soo-Jin
Kim Jin-Woong
Son Eui-Dong
Yoo Ik-Dong
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Abstract
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We found that silymarin exhibited the inhibitory effect on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Silymarin is a standardized extract obtained from the dried seeds of milk thistle (Silybum marianum Gaertn.). Silymarin significantly prevented melanin production in a dose-dependent manner with an IC50 value of 28.2 μg/mL without effects on cell viability. Also, silymarin inhibited tyrosinase activity in melanocyte, while it did not affect the catalytic activity of cell-free tyrosinase. Furthermore, Western blot analysis indicated that silymarin decreased the expression of tyrosinase protein. Silybin A/B and isosilybin A/B were also able to inhibit melanin production and tyrosinase expression in protein level. Double blind study on the clinical efficacy of a cream containing 2 % silymarin showed that silymarin have a significant skin whitening effect. Therefore, this study suggests that silymarin may be useful as a natural skin whitening agent.
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KEYWORD
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melanogenesis, silymarin, tyrosinase activity, silybin, skin whitening
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